Metanephrines (24 Hr), Urine

Additional Info: Test includes metanephrine, normetanephrine, and total metanephrines

Useful For:
Test is useful in the evaluation of pheochromocytoma.

Methodology: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Specimen Requirements: Submit an entire 24-hour urine collection in a urine container supplied by Meadville Medical Center Laboratory. Add 25 mL of 6N HCL as preservative at start of collection. This preservative is intended to maintain a pH below 3.0. Refrigerate specimen during and after collection.


  • Patient should avoid tobacco, tea and coffee 3 days prior to specimen collection.
  • Patient should discontinue medications 3 days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha, and beta blockers) cause minimal or no interference.
  • Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.
  • Urine without a preservative is acceptable if pH is below 6.0 and sample is shipped frozen.

Analytical Time: 5 days

Days Set Up: Monday through Friday

CPT Information:
83835 – metanephrines, total