Useful For:
This test is performed to detect the molecular rearrangement of the bcr and abl genes involved in translocation 9,22, associated with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), using FISH (fluorescence in situ hybridization). This test may be used in the evaluation of Ph negative CML, complex rearrangements or for follow-up to therapy for previously diagnosed Ph+ patients.
Methodology: Fluorescence in Situ Hybridization (FISH)
Specimen Requirements:
Bone Marrow – Collect 2-3 mL bone marrow in 1 green-top (sodium heparin) tube. Store specimen at room temperature after collection.
Blood – 1 green-top (sodium heparin) tube (minimum: 5-6 mL of heparinized whole blood). Store specimen at room temperature after collection.
NOTE :Refrigerated or frozen specimens are unacceptable.
Analytical Time:
5 days
Days Set Up: Monday through Thursday AM
CPT Information:
Computer-assisted: 88637, 88373, 88374
Manual: 88368, 88369, 88377